Comparison of Meperidine and Tenoxicam For Pain Management in Trauma Patients

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Year-Number: 2022-Vol: 1 Issue: 3 PP: 51-75
Number of pages: p- 63-6
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Abstract

Aim: The aim of this study was to compare the effectiveness and side effects of meperidine and tenoxicam, either alone or in combination for the pain management of trauma patients.
Materials and Methods: This was a prospective, single-center, single-dose, randomized, double-blind study in trauma patients (age≥16) with Glasgow coma scale (GCS) 15, stable hemodynamics and initial visuel analog scale (VAS) score of 50 mm or higher. Sixty patients  were randomized to one of  the three treatment groups. All patients vital signs, VAS scores and adverse events were recorded before the drug administrations  and at 15, 30, 60 minutes  of applications. 
Results: The mean initial VAS for meperidin, tenoxicam and meperidin + tenoxicam groups were 83±13, 82±15 and 76±15, respectively. The  mean final VAS for these gruops were 5.0±1.8, 4.9±2.2 and  4.3±2.3, respectively. The decreases of VAS for all groups and time periods were statistically significant and there were not any significant difference between the groups. Furthermore,  no serious adverse events were observed.
Conclusion: In conclusion, in addition to it’s advantages like rendering possible intravenous administration and not having direct effects on vital functions, tenoxicam is as effective as meperidine  for acute severe pain.

 

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