Correlation of C-Reactive Protein/ Lymphocyte Ratio with Mortality in Patients Diagnosed with COVID-19 in the Emergency Department
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Abstract
Abstract
Aim: Studies have shown that CRP/lymphocyte ratio (CLR) is a better predictor of prognosis compared to the use of CRP or lymphocyte count alone. The aim of this study is to reveal the relationship of CLR with early mortality in patients hospitalized for COVID-19.
Materials and Methods: The study is a retrospective observational study. Patients aged 18 years and over, who admitted to the emergency department between March 11, 2020 and December 31, 2020, whose PCR test results were positive, and whose treatment was decided to be inpatient, were included in the study. The time interval for mortality is 28 days. The data recorded in the study form were analyzed with the IBM SPSS 20.0 statistical program.
Results: In addition to CRP, lymphocyte and CLR values, troponin, ferritin, and d-dimer values, which have been shown to have prognostic significance in current studies, were found to be statistically significantly different between the groups with and without mortality (p<0.001 for all values). Although the AUC value of CLR was 0.834, higher than CRP (AUC=0.808) and lymphocyte (AUC=0.696), the Delong test showed that the difference in the areas under the curve of CLR and CRP values was not statistically significant (p=0.163). Considering the power of other parameters to predict mortality, there was no significant difference between CRP, CLR and D dimer AUC values, while troponin AUC value was significantly higher than all other parameters, and ferritin AUC value was significantly lower than all other parameters.
Conclusion: This study showed that the CLR value has a high prognostic value in terms of mortality in COVID-19 patients. While the prognostic power of CLR is significantly higher compared to the lymphocyte count alone, although it provides a numerical superiority compared to CRP, this difference is not statistically significant.